Genetic Changes Leading to Antibiotic Resistance in Clinical Isolates of Escherichia coli

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  • The spread of antibiotic resistance has limited the use of antibiotics in clinical settings, resulting in a huge threat to public health worldwide. Multidrug resistance causes thousands of deaths annually and is currently a significant financial burden in many countries. In this study, clinical isolates of Escherichia coli with varying drug resistance profiles were used to understand the genetic changes contributing to quinolone and β-lactam resistance. Novel genetic changes in gyrA and gyrB genes, known to contribute to quinolone resistance, were recorded. Furthermore, the CTX-M-14 and -15 genes were found in most β-lactam resistance strains. Significant correlations between mutations in novel genes and various phenotypic data were also observed, suggesting a role for these genes in determining these phenotypes. This work further increases our knowledge regarding causes of antibiotic resistance in clinical strains and lays foundation for future research.

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  • Copyright © 2016 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
Date Created
  • 2016


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