Sex Differences in the Behavioural Response to FGF2 Administration

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  • Anxiety is one of the most prevalent psychiatric disorders in Canada, but its etiology is not yet fully known. The current treatments for anxiety disorders have considerable limitations, making it necessary for research to explore new therapeutic targets and treatments. Recent research has identified the use of FGF2 as a potent endogenous anxiolytic factor. The present study examined a maternal separation rodent model of anxiety to mimic early life parental separation in humans. Following adult treatment with vehicle control or FGF2, rats were tested on depressive and anxiety-like behavioural measures. Results did not show an effect of maternal separation stress on anxiety; however, there was a sex-specific response to FGF2 in controls, such that females appeared to respond better to FGF2 administration than males. Future research will be needed to delineate these sex-specific differences in FGF2's anxiolytic potential in order to understand the generalizability of its therapeutic potential.

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  • Copyright © 2018 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
Date Created
  • 2018


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