Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts

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  • Nanosilver is extremely small silver particles (1-100 nm in diameter) and have antimicrobial, antifungal, and antiviral properties, which make them one of the most commonly used nanoparticles. There is a lack of biological and toxicological knowledge on the impacts of nanosilver on cellular stress responses, as well as human and environmental health. Nanosilver and ascorbic acid has the potential to be an anticancer therapeutic. In this study, human colon cancer (HCT116) and intestinal epithelial (HIEC-6) cells were used to study nanosilver effects in cancer versus non-cancer cells. Nanosilver increased Nrf2 protein expression and disrupted the cell cycle at the G1 and G2/M phases. Hypoxia attenuated nanosilver-induced oxidative and endoplasmic reticulum stress responses. Nanosilver induced significant mitochondrial oxidative stress in HCT116, whereas it did not in the non-cancer HIEC-6 and nanosilver/sodium ascorbate co-treatment was preferentially lethal to HCT116 cells, which is promising for further research for anticancer therapies.

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  • Copyright © 2022 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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  • 2022


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