Development of Spatial Function in Rats and Associated C-Fos Patterns in the Hippocampal CA1 and CA3 Regions

Public Deposited
Resource Type
  • The hippocampus shows connectivity-based changes during development. The current work investigated the contribution of performance and cognitive factors in the emergence of spatial function during development. Experiment one showed a sensitive developmental period exists between 16 days old (p16) and p24. Experiment two found impaired performance on spatial learning following NMDAr blockade. Experiment three explored one-day of water maze training at p16, p18, or p20 and spatial learning was established only at p20. Quantification of c-Fos positive cells in CA3 and CA1 revealed a main effect of age. Lastly, rats were trained on the dry maze at: p16, p17, p18, p19, or p20. Groups p19 and p20 demonstrated spatial learning. Quantification of c-Fos positive cells in CA1 revealed a main effect of age. This suggests that spatial memory mechanisms emerge at p19/p20 independently from performance factors and are based on hippocampal function.

Thesis Degree Level
Thesis Degree Name
Thesis Degree Discipline
Rights Notes
  • Copyright © 2013 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
Date Created
  • 2013


In Collection: