Sex differences in the asymmetry of the Nigrostriatal Dopamine system : relationship to spatial ability in the rat

Public Deposited
Resource Type
  • The present study investigated the relationship between the asymmetry of the nigrostriatal dopamine system, amphetamine-induced rotation and spatial ability. In addition, the influence of the gonadal hormones on this relationship was investigated. Half of the 40 female and of the 40 male Wistar rats were gonadectomized while the remaining underwent a sham operation. The rats were tested on two consecutive weeks for their rotational behavior following administration of amphetamine (1.2 mg/kg). Spatial ability was measured on a modified Lashley III maze for half of the animals. The remaining animals were tested on the Morris Water maze. Followingcompletion of the tests of spatial ability, the animals were sacrificed by decapitation and their brains (right and left striata and right and left frontal cortices) were dissected, and later assayed for their contents of DA and NE by the fluorometric method. Gonadectomy was found to increase striatal DA levels, and to influence performance of male rats on the Lashley III maze. The relationship between spatial ability and the asymmetry of the DA system was task-specific since a correlation was found only with performance on the Lashley III maze and not on the Morris Water maze. The results also showed that the relationship between rotation and spatial ability was influenced by the sex and the treatment of the animals.

Thesis Degree Level
Thesis Degree Name
Thesis Degree Discipline
Access Rights
Rights Notes
  • Copyright ¬© 1988 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
Date Created
  • 1988


In Collection: