Interactive Effects of a Social Stressor and Interleukin-6 Injection on Anxiety-Related Behaviors and Expression of Pro-Inflammatory Factors in Male CD-1 MicePublic Deposited
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Stressful events induce a range of neurochemical and endocrine changes as part of the brain’s adaptive response to such challenges. If the organism is repeatedly stressed, the development or exacerbation of psychopathologies, such as depression and anxiety, can ensue. A potential role for inflammatory factors in these disorders has emerged. In the present experiment, we investigated whether a challenge with interleukin (IL)-6, a pro-inflammatory cytokine commonly associated with depression, elicits anxiety-related behaviours and alters brain expression of inflammatory factors in CD-1 mice, and whether this differed based on the social stressor backdrop on which the cytokine was applied. The combination of an acute social stressor coupled with IL-6 injection enhanced expression of IL-1β, IL-6, and SOCS3 in a time- and brain region- dependent manner. The current results are consistent with the perspective that stress acts on the JAK/STAT pathway to enhance expression of certain pro-inflammatory factors, possibly leading to pathologies.
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- Copyright © 2013 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
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