The Role of Fibroblast Growth Factor 2 in Energy Balance and Metabolism

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  • Fibroblast growth factor 2 (FGF2) is exclusively expressed by astrocytes and has hypophagic and weight reducing effects. The objective of this study is to further elucidate the role of FGF2 on feeding and energy balance using FGF2 KO animals. Mice were exposed to regular chow or a 60% high fat diet over the course of 6 weeks. We hypothesized FGF2KO animals would exhibit hyperphagia and weight gain, and that this would augment in the presence of a high fat diet. Results demonstrated both WT and FGF2KO animals gained weight similarly and had similar caloric intake when ingesting high fat diet. Carbohydrate expenditure was increased in male KO's and female KO's had increased ambulatory counts during the night phase. Future studies should investigate the effects of stressed FGF2KO animals on HFD and should continue to explore the circuitry involved in energy balance and regulation.

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  • Copyright © 2019 the author(s). Theses may be used for non-commercial research, educational, or related academic purposes only. Such uses include personal study, research, scholarship, and teaching. Theses may only be shared by linking to Carleton University Institutional Repository and no part may be used without proper attribution to the author. No part may be used for commercial purposes directly or indirectly via a for-profit platform; no adaptation or derivative works are permitted without consent from the copyright owner.
Date Created
  • 2019


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