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  • Understanding the Experience of Advance Care Planning for Older Adults Transitioning into Long-Term Care Homes

    Resource Type:
    Thesis
    Creator:
    Thomas, Madeline Campbell
    Abstract:
    During the transition to long-term care (LTC), conversations that prepare individuals and their families for the possibility that the individual may be unable to make healthcare decisions in the future are often overlooked. This research uses a service design approach to understand the LTC transition experience in Ontario with attention to advance care planning. This case study involved qualitative methods to document the perspectives of LTC and advance care planning subject matter experts; and care partners of older adults who transitioned into LTC. This included unstructured interviews with experts; semi-structured interviews with care partners; and follow-up sessions with participants. Results showcased the complicated LTC journey in Ontario and the lack of an integrated approach to advance care planning. Despite the efforts of healthcare workers, many Ontarians have an incomplete understanding, even after transitioning to LTC. Applying service design within this context demonstrated strengths and limitations of the current approach.
    Thesis Degree:
    Master of Design (M.Des.)
    Thesis Degree Discipline:
    Industrial Design
    Date Created:
    2023

  • Valuable Materials, Invaluable Relationships: Exploring Indigenous Culture and Sovereignty Through Moose and Caribou Hair Tufting in the NWT

    Resource Type:
    Thesis
    Creator:
    Wenzel, Abra
    Abstract:
    Moose and caribou hair tufting is an important Subarctic women's artform in the Mackenzie Valley, Northwest Territories. However, tuftings and tufters have historically been identified following non-Indigenous ideologies rooted in colonialism and capitalist values, resulting in labels such as "craft", and "artisan", that are difficult to change. This practice has undervalued, if not dismissed, Indigenous artists, their artistry and by and large their art. This dissertation takes a multi-sited approach using archival records, museum objects, and interviews with tourism shop employees, and especially with tufting artists to elucidate the complex ways artists have employed their art to traverse cultural borders. In tracing the history of tufting, I discuss how women have used their artistry as acts of agential resistance to re-assert their own cultural and place-rooted relationships and meanings in the face of centuries of colonial violations. The central objective of my research is to make clear the dimensions of significance engaged with in hair tuftings by Dene, Métis, and Inuvialuit artists. I show how important values such as skill, landscape, and culture are a connected whole that is embodied within each tufting. A second objective is to uncover how important Indigenous values were and continue to be impacted by colonization. In my early chapters, I explain how Western values were imposed on Indigenous peoples and livelihoods. Thus, the Indigenous values attached to artistic making were regarded as inferior as viewed through Western critics' lenses. Third, I discuss the ways tufters have used their creations as sites of sovereignty to continuously negotiate and challenge colonial endeavors and carry these vital knowledges and values into the future. A critical outcome of this research has been the deconstruction of the colonial spaces that have silenced Indigenous peoples and their textile creations. Here I have offered a revisionist narrative that is informed by artists, Elders, and community members to provide a critical understanding of the multiplicity of values that are essential to Indigenous societies. Finally, this dissertation reflects on my positionality as an anthropologist and highlights to importance of "listening" as a methodology.
    Thesis Degree:
    Doctor of Philosophy (Ph.D.)
    Thesis Degree Discipline:
    Anthropology
    Date Created:
    2023

  • Ontario youth workers' discourses on overrepresentation of Indigenous youth in the criminal legal system

    Resource Type:
    Thesis
    Creator:
    Venczel, Elizabeth
    Abstract:
    In an age of reconciliation, following the TRC's recommendations and the work of activists, the issue of Indigenous youth overrepresentation in the criminal legal system is being problematized more than ever. Although the use of incarceration towards criminalized youth has decreased since the adoption of the YCJA which emphasizes diversion, the overrepresentation of Indigenous youth has increased. This thesis explores the discourses and experiences of youth workers in Ontario in order to understand their perspectives on the problem of overrepresentation, focusing particularly on the critical role of the police in filtering in or out criminalizable youth. Although the youth workers interviewed in this project identify many contemporary issues in the policing of Indigenous youth, their discourses reveal the limits of attempts to tackle the problem of overrepresentation through reforms of criminal legal frameworks and institutions.
    Thesis Degree:
    Master of Arts (M.A.)
    Thesis Degree Discipline:
    Legal Studies
    Date Created:
    2023

  • Application of Genomics-Based Methodologies in Genetic Toxicology to Advance In Vitro Chemical Assessment

    Resource Type:
    Thesis
    Creator:
    Cho, Eunnara
    Abstract:
    The current standard regulatory tests in genetic toxicology are inadequate for effectively addressing the growing number of chemicals needing assessment. Specifically, the standard in vitro assays do not provide sufficient mechanistic information to inform relevance to in vivo toxicity. The resulting reliance on in vivo models in regulatory toxicology has hindered efficient chemical assessment. Thus, international efforts are underway to reduce animal testing and modernize toxicity assessment by developing and promoting non-animal alternatives, or new approach methodologies (NAMs). The goal of my thesis was to develop and demonstrate the application of genomics NAMs for quantifying genotoxic hazards and obtaining information on mechanism of action to advance in vitro chemical assessment. First, the inter-platform transferability of the TGx-DDI biomarker of DNA damage-induction was investigated. TGx-DDI is a 64-gene biomarker developed using DNA microarrays in human TK6 cells that provides mechanistic support to conventional genotoxicity assays. The biomarker demonstrated a conserved performance when measured by qPCR, demonstrating that transcriptomic biomarkers can be adapted to this widely available platform. Additional chemical testing methods were explored using two next-generation sequencing-based technologies: TempO-Seq, a targeted gene expression platform, and Duplex Sequencing (DuplexSeq), an emerging technology that enables direct and accurate detection of mutations in cells. A transcriptomic biomarker of histone deacetylase inhibition, TGx-HDACi, was developed from TempO-Seq whole transcriptome profiles to address the limited assays available for detecting epigenetic mechanisms of toxicity. The availability of TGx-HDACi contributes to diversifying the transcriptomic biomarkers that can be applied in high-throughput screening of transcriptomic profiles of chemicals. Next, a comparative, inter-laboratory study in TK6 cells identified an optimal experimental design for applying DuplexSeq as a mutagenicity assay. DuplexSeq detected a robust concentration-response in cells exposed to an alkylating agent, with high sensitivity. The results also revealed strong inter-laboratory reproducibility and the power of DuplexSeq in providing a comprehensive view of chemical-induced mutagenesis. Lastly, an Adverse Outcome Pathway (AOP) describing oxidative DNA damage leading to chromosomal aberrations and mutations was developed to provide a mechanistic framework for combining NAMs in integrated testing. Collectively, my thesis lays the foundation for development and advancement of NAMs and AOPs in genetic toxicology.
    Thesis Degree:
    Doctor of Philosophy (Ph.D.)
    Thesis Degree Discipline:
    Biology
    Date Created:
    2023

  • Survey on the Irreducible Representations of Lie Algebras and Lie Groups

    Resource Type:
    Thesis
    Creator:
    Zhou, Yuanxiang
    Abstract:
    Lie groups and Lie algebras are central objects in differential geometry and physics. Representing Lie groups and algebras as spaces of linear operators is one of the most powerful tools to understand their structures. In our thesis, we introduce the class of matrix Lie groups and algebras with focus on simply connected Lie groups and semisimple Lie algebras. To obtain the irreducible representation for semisimple Lie algebras, we construct the Verma module and obtain a finite-dimensional irreducible quotient space based on the Verma module. The Weyl's character formula, whose consequences include Weyl's dimension formula and Kostant's multiplicity formula, gives informative data to the irreducible representations. Lastly, nested special orthogonal algebras are investigated to obtain a generalization of Weyl's character formula together with a demonstrative application of Weyl's dimension formula and Kostant's multiplicity formula.
    Thesis Degree:
    Master of Science (M.Sc.)
    Thesis Degree Discipline:
    FLAG
    Date Created:
    2023

  • Studying the Generation of Hot Electrons in Plasmonic Nanoparticle Monolayers

    Resource Type:
    Thesis
    Creator:
    Baril, Jimmy Milton
    Abstract:
    Hot electrons are generated from the decay of LSPR modes. Surface-enhanced Raman spectroscopy is used to monitor hot electron generation using a dehalogenation reaction. In this thesis, Ag, Au, and AuAg nanoparticle substrates were produced and coated with halogenated thiophenols. The dipole and coupled LSPR modes associated with the nanoparticle substrate both generate hot electrons under illumination. The hot electron yield was determined for each LSPR modes. It was found that the dipole LSPR mode produced a larger yield of hot electrons than the coupled LSPR mode. The enhanced hot electron yield for the dipole mode was reported for both Ag-slides and AuAg-slides; additionally, the same result was obtained for both halogenated thiophenols. This work shows that the dipole LSPR mode is more suitable for the generation of hot electron than the coupled mode. Additional work is required to make the coupled LSPR mode an efficient hot electron generator.
    Thesis Degree:
    Master of Science (M.Sc.)
    Thesis Degree Discipline:
    Chemistry
    Date Created:
    2023

  • System Analysis for Satellite Networks with Free-Space Optical Links

    Resource Type:
    Thesis
    Creator:
    Liang, Jintao
    Abstract:
    In this thesis, we analyze several system parameters and performances for free-space optical satellite networks (FSOSNs), including phasing parameter, optical satellite link budget, tradeoff between network latency and satellite transmission power, and network latency minimization based on satellite transmission power constraints. We investigate the phasing parameter for Starlink Phase 1 Version 3 and Kuiper Shell 2 constellations. We find the best value of the phasing parameter. We investigate the link budget for laser inter-satellite link (LISL) and uplink/downlink and the effect of many constellation parameters on the satellite transmission power. We examine the tradeoff between network latency and satellite transmission power in FSOSNs from Starlink Phase 1 Version 3 and Kuiper Shell 2 constellations for different LISL ranges and inter-continental connections. We investigate the minimization of total network latency in the FSOSN resulting from Starlink Phase 1 Version 3 constellation for different LISL ranges and satellite transmission power constraints.
    Thesis Degree:
    Master of Applied Science (M.App.Sc.)
    Thesis Degree Discipline:
    Engineering, Electrical and Computer
    Date Created:
    2023

  • Aptamer Technology for Diabetes and Co-Morbidities

    Resource Type:
    Thesis
    Creator:
    Ferguson, Madison Quinn
    Abstract:
    Given that the number of people who are diagnosed with diabetes continues to rise at an alarming rate, there is a pressing need for therapeutic interventions that are either more efficient or potentially curative. Furthermore, comorbidities such as kidney failure, thrombosis, thyroid dysfunction, Alzheimer's disease, and an increased risk of severe illness from common viral and bacterial infections are more likely to occur in people who have type 2 diabetes. The advancement of nanotechnology may lead to the diagnostics and therapies that could improve the survival and quality of life of patients with diabetes. Aptamers are oligonucleotides that have the ability to bind to a particular target with a high degree of specificity as well as affinity. Systematic evolution of ligands by exponential enrichment (SELEX) is an in vitro evolution method that is responsible for the generation of aptamers. It has been shown that aptamers may function as medicines, diagnostics, theragnostics, targeted delivery vehicles, responsive materials and more. This work examines the application of aptamers to diabetes and related comorbidities. The selection and preliminary characterization of aptamers able to interact with Islet amyloid polypeptide (IAPP), a potential causative factor in the development of type II diabetes, are described. An aptamer-based diagnostic for the acute kidney failure biomarker neutrophil gelatinase lipocalin protein is also developed. An aptamer-modified janus nanoparticle system is investigated as a potential theragnostic for thrombosis that could combine photothermal therapy and magnetic resonance imaging. Finally, aptamers for the spike protein component 2 of SARS-CoV2 and a database for aptamer selection experiments are briefly described.
    Thesis Degree:
    Doctor of Philosophy (Ph.D.)
    Thesis Degree Discipline:
    Chemistry
    Date Created:
    2022

  • Behavioural and Neurological Effects of Fructose Cessation and Reexposure

    Resource Type:
    Thesis
    Creator:
    Sankhe, Aditi Sajjala
    Abstract:
    Fructose is a monosaccharide present in food items consumed, and its increased consumption over time has increased development of metabolic diseases, such as obesity. Findings from our lab showed that fructose consumption increased excitatory tone onto orexigenic neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons of the arcuate nucleus (ARC). This tone is reversible with cessation after one week of fructose consumption, but it is not known if the increased excitatory tone is reversible with cessation from chronic fructose consumption. We used whole-cell patch-clamp recordings and a fructose choice test to assess if fructose cessation could revert excitatory tone at NPY/AgRP neurons or enhance fructose preference upon re-exposure. We have found that fructose abstinence reverted increased excitatory tone at NPY/AgRP neurons in males. Continuous fructose consumption reduced preference for fructose, but fructose cessation enhanced it. These findings suggest that fructose cessation reverts increased excitatory tone but can also increase future fructose intake.
    Thesis Degree:
    Master of Science (M.Sc.)
    Thesis Degree Discipline:
    Neuroscience
    Date Created:
    2022

  • Assessment of Solar Assisted Heat Pump Configurations in Canada

    Resource Type:
    Thesis
    Creator:
    Beauchamp, Benjamin
    Abstract:
    This thesis discusses the energy savings, performance, and cost savings of various SAHP typologies in Canada, focusing on parallel systems. Typologies are evaluated for two detached housing archetypes, across a variety of Canadian climates. Modelling takes place in two stages. A first stage using a spreadsheet tool to determine which typology holds the most potential followed by a more detailed second stage in TRNSYS to investigate it. The first stage found that parallel SAHPs hold the most potential. The second stage found that parallel systems provided significant savings across all cities and housing archetypes. A combination of SDHW and ASHP outperformed the parallel system at low collector areas. However, no predicted savings were high enough to payback the predicted installation costs. This document explains the models, assumptions, and results. Recommendations are discussed for future research on system sizing, typologies of interest, heat pump modelling, and component costing.
    Thesis Degree:
    Master of Applied Science (M.App.Sc.)
    Thesis Degree Discipline:
    Engineering, Mechanical
    Date Created:
    2023